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The direct relevance of these interconnected markers is underscored by preclinical evidence showing that MDMA-induced cytoskeletal damage causes a reduction in intracellular NfL, an effect that is partially rescued by the neuroprotective action of BDNF, thus providing a mechanistic link between the neurotrophic and neurodegenerative pathways that can be monitored in clinical trials [156]

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The peptides were analyzed using a nano-UPLC coupled to a timsTOF Pro2 instrument